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Indications

• Varenicline is used by adults to aid in smoking cessation. To enhance the likelihood of success, it is recommended to use this medication alongside a comprehensive stop-smoking program that includes education, support, and counseling.
• Quitting smoking is associated with a reduction in the risk of heart and lung disease, as well as cancer. Varenicline operates by blocking the effects of nicotine in the brain that contribute to the desire to smoke.
• Have a discussion with your doctor regarding the risks and benefits of this medication, as well as exploring other methods for quitting smoking, such as nicotine replacement treatment.

Dosage and administration

• Before starting varenicline, read the Medication Guide provided by your pharmacist. If you have any questions, consult your doctor or pharmacist.
• There are different approaches to using varenicline. One method involves setting a quit date before starting treatment. Begin taking varenicline as directed by your doctor, 1 to 2 weeks before the quit date. The initial dose is one 0.5-milligram tablet daily for 3 days, followed by one 0.5-milligram tablet twice daily for 4 days. The dosage gradually increases to minimize side effects. It is permissible to smoke during this period. Cease smoking on the quit date and continue taking the prescribed dose twice daily for the remaining treatment period (usually 12 weeks).
• Another approach is to start taking varenicline before selecting a quit date. Initiate with the 0.5-milligram tablets and increase the dose as directed by your doctor. Choose a quit date between days 8 and 35 of treatment and stop smoking on that date. Take the prescribed dose for the remainder of the treatment period.
• If unable to select a quit date, your doctor may instruct you to start taking the medication and gradually reduce smoking with the goal of quitting by the end of the treatment. Follow your doctor’s instructions carefully and reduce smoking as directed.
• If the medication comes in a dosing package, follow the directions on the package (starting pack or continuing pack) containing different strengths of the medication. If it comes in a bottle, adhere to your doctor’s instructions on the prescription label. If unsure about how to take the medication, consult your doctor or pharmacist.
• Take this medication orally after eating and with a full glass of water. The dosage is determined by your medical condition and response to treatment.
• Do not exceed the prescribed dose or take the medication more frequently than directed. Taking more than 1 milligram twice a day is not recommended.
• Take the medication regularly at the same time(s) each day to maximize its benefits.
• Inform your doctor if you continue smoking after a few weeks of treatment. If unable to quit smoking after 12 weeks, consult your doctor.
• If successful and cigarette-free after 12 weeks, your doctor may recommend an additional 12 weeks of treatment with varenicline.

Side effects

• Possible side effects of varenicline may include nausea, headache, vomiting, drowsiness, gas, constipation, trouble sleeping, unusual dreams, or changes in taste. Inform your doctor or pharmacist promptly if these effects persist or worsen.
• It’s important to note that the prescribed medication is deemed beneficial by your doctor, and many individuals using it do not experience serious side effects.
• Notify your doctor immediately if you experience serious side effects such as a burning feeling in feet/toes or unusual pain in the legs when walking.
• Stop taking varenicline and seek medical help promptly if you encounter very serious side effects, including seizures, symptoms of a heart attack (chest/jaw/left arm pain, shortness of breath, unusual sweating), signs of a stroke (weakness on one side of the body, trouble speaking, sudden vision changes, confusion), or harmful behavior to self/others/property.
• In rare cases, varenicline may lead to serious mental/mood changes, even after discontinuing the medication. Drinking alcohol while using varenicline may increase the risk of mental/mood changes. Quitting smoking itself can also trigger such changes. Cease varenicline and notify your doctor or pharmacist promptly if you experience symptoms like depression/suicidal thoughts, agitation, aggression, or other unusual thoughts or behavior.
• While a severe allergic reaction to this drug is rare, seek immediate medical assistance if you observe symptoms such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
• The listed side effects may not cover all possibilities. If you notice other effects not mentioned, contact your doctor or pharmacist.

Precautions

• Before taking varenicline, inform your doctor or pharmacist about any allergies you may have, as inactive ingredients in the product could cause allergic reactions or other issues. Seek advice from your pharmacist for more details.
• Provide your medical history to your doctor or pharmacist before using this medication, especially if you have kidney disease, mental/mood disorders (such as schizophrenia, bipolar disorder, depression), heart/blood vessel disease (such as coronary artery disease, peripheral vascular disease, stroke), or a history of seizures.
• This drug may induce dizziness, drowsiness, loss of consciousness, or difficulty concentrating. Alcohol or marijuana (cannabis) can exacerbate these effects. Refrain from driving, operating machinery, or engaging in activities that require alertness until you can do so safely. Discuss your marijuana use with your doctor.
• Varenicline may heighten sensitivity to alcohol, leading to increased drunkenness, unusual behavior, and limited or no memory of events. Limit alcohol consumption and be mindful of its effects while taking this medication.
• During pregnancy, use this medication only when necessary, and discuss potential risks and benefits with your doctor.
• It’s uncertain whether this medication passes into breast milk. Consult your doctor before breastfeeding.