Indications
- Acetazolamide prevents and alleviates altitude sickness symptoms.
- Symptoms include headache, tiredness, nausea, dizziness, and shortness of breath.
- Effective above 10,000 feet/3,048 meters.
- Useful for rapid ascents.
- Best prevention methods: slow climbing, rest stops, easy activity for 1-2 days.
- Also treats high eye pressure in glaucoma.
- Belongs to carbonic anhydrase inhibitors class.
- Reduces fluid production in the eye.
- Treats edema from heart failure or certain medications.
- Usage typically short-term due to decreased effectiveness over time.
- Used with other drugs for certain seizures.
Dosage and administration
- Take tablets 1-4 times daily, or long-acting capsules 1-2 times daily as directed by doctor.
- Swallow capsules whole, don’t open, break, or chew.
- Can be taken with or without food.
- Drink plenty of fluids unless directed otherwise.
- Dosage based on medical condition and response.
- Start acetazolamide 1-2 days before climbing for altitude sickness prevention.
- Continue during climb and for 48 hours after reaching final altitude.
- May need to continue at high altitude to control symptoms.
- Severe altitude sickness requires immediate descent.
- Regular use for other conditions like glaucoma or seizures for maximum benefit.
- Take consistently at same time(s) each day.
- Taking last dose early evening helps prevent night-time urination.
- Don’t increase dose or use more often/longer than prescribed.
- Extended use may require different dosing, doctor monitors condition.
- Inform doctor if no improvement or worsening condition.
- Medication may lower potassium levels; eat potassium-rich foods or take supplements as directed by doctor.
- Inform doctor if condition persists or worsens.
Side effects
- Possible side effects: dizziness, lightheadedness, increased urination, blurred vision, dry mouth, drowsiness, loss of appetite, nausea, vomiting, diarrhea, changes in taste.
- Inform doctor/pharmacist if side effects persist or worsen.
- Rise slowly from sitting or lying down to reduce dizziness/lightheadedness risk.
- Medication prescribed considering benefits outweigh risks.
- Serious side effects may include tingling of hands/feet, hearing loss, ringing in ears, unusual tiredness, easy bleeding/bruising, irregular heartbeat, muscle cramps/pain, new or worsening eye pain, vision changes, mental/mood changes, signs of liver or kidney problems, signs of infection.
- Seek immediate medical help for signs of serious allergic reaction: rash, itching/swelling, severe dizziness, trouble breathing.
- Not a complete list of possible side effects; contact doctor/pharmacist for other effects.
Precautions
- Inform doctor/pharmacist of allergies, medical history, including adrenal gland problems, mineral imbalances, dehydration, kidney/liver disease, breathing problems, diabetes, gout, narrow-angle glaucoma, overactive thyroid.
- Medication helps acclimate to high altitudes but doesn’t prevent serious altitude sickness.
- Symptoms of serious altitude sickness include severe shortness of breath, mental/mood changes, lack of coordination, extreme tiredness, severe headache; descend to lower altitude if experienced.
- May cause dizziness, drowsiness, or blurred vision; avoid driving, operating machinery, or activities requiring alertness until safe.
- Alcohol or marijuana can increase dizziness or drowsiness; limit consumption.
- Monitor blood sugar levels regularly, especially if diabetic; report symptoms of high or low blood sugar to doctor.
- May increase sensitivity to sun; limit sun exposure, use sunscreen, wear protective clothing; report sunburn or skin irritation to doctor.
- Inform healthcare provider of all medications used, including prescription, nonprescription, and herbal products, before surgery.
- Older adults may be more sensitive to effects, particularly dizziness and lightheadedness.
- Use during pregnancy only if clearly needed; discuss risks and benefits with doctor.
- Consult doctor before breastfeeding; medication passes into breast milk but unlikely to harm infant.