Indications
- Sensipar is indicated for the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease on dialysis.
- It is also prescribed for the treatment of hypercalcemia in adult patients with parathyroid carcinoma.
- Sensipar is used in the management of hypercalcemia in adult patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy.
- Additionally, it is indicated for the reduction of elevated calcium levels in pediatric patients (ages 3 years and older) with primary hyperparathyroidism, including patients with multiple endocrine neoplasia type 1 (MEN1).
Dosage and administration
- The recommended starting dose of Sensipar for adults with secondary hyperparathyroidism due to chronic kidney disease is 30 mg once daily.
- Dosage adjustments should be made based on serum calcium levels, with increases or decreases in 30 mg increments as needed.
- The maximum recommended dose of Sensipar is 180 mg once daily.
- Sensipar can be taken with or without food.
- Swallow the tablet whole with water and do not crush, chew, or break it.
- Regular monitoring of serum calcium levels is essential to adjust the dosage of Sensipar appropriately.
- Dosage adjustments may also be necessary if the patient experiences changes in liver function or if they are taking certain medications that may interact with Sensipar.
- Always follow your doctor’s instructions regarding dosage adjustments and administration of Sensipar.
Side effects
- Common side effects of Sensipar may include nausea, vomiting, diarrhea, and loss of appetite.
- Some patients may experience dizziness or headache while taking Sensipar.
- Muscle or joint pain, weakness, or cramping may occur as a side effect.
- Sensipar can cause low levels of calcium in the blood (hypocalcemia), leading to symptoms such as numbness or tingling around the mouth, fingers, or toes.
- Other potential side effects include fatigue, difficulty sleeping (insomnia), or feeling anxious.
- Serious side effects of Sensipar may include seizures, irregular heartbeat, or worsening kidney function.
- Allergic reactions to Sensipar are rare but can include rash, itching, swelling, severe dizziness, or trouble breathing.
- Report any side effects to your doctor promptly, especially if they are severe or persistent.
Precautions
- Inform your healthcare provider about all medical conditions you have, especially if you have a history of seizures, heart problems, or liver disease.
- Notify your healthcare provider about all medications you are currently taking, including prescription, over-the-counter, and herbal supplements, to avoid potential drug interactions.
- Attend all scheduled appointments for monitoring of serum calcium levels and other relevant laboratory tests as directed by your healthcare provider.
- If you develop symptoms of hypocalcemia, such as tingling around the mouth, fingers, or toes, notify your healthcare provider promptly.
- Avoid sudden discontinuation of Sensipar without consulting your healthcare provider, as it may lead to rebound hypercalcemia.
- If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Sensipar with your healthcare provider before starting or continuing treatment.
- Keep Sensipar out of reach of children and pets, as accidental ingestion may cause serious harm.
- Store Sensipar at room temperature away from moisture and heat sources.